Causes tissue to overgrow, harden, and scar due to chronic inflammation
Chronic fibrosis can create an environment conducive to cancer development. For example, in liver cirrhosis (a form of fibrosis), there is an increased risk of liver cancer (hepatocellular carcinoma). Similarly, pulmonary fibrosis has been associated with an increased risk of lung cancer.
Fibrosis plays a significant role in cancer biology, influencing tumor progression, metastasis, and treatment response. The fibrotic microenvironment can create conditions that support tumor growth and resistance to therapies, often correlating with poor prognosis across various cancer types.
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