MARK4 is involved in phosphorylating microtubule-associated proteins. This phosphorylation modulates microtubule stability and dynamics, which are important for processes like cell division, intracellular transport, and maintaining cell structure.
- Dysregulation of MARK4 has been observed in various cancers, contributing to tumor growth, invasion, and metastasis.
• Many studies have found that MARK4 is often upregulated in cancers such as breast cancer, glioma, and hepatocellular carcinoma.
• Higher expression of MARK4 in these settings has been associated with a poorer prognosis, including greater tumor aggressiveness and lower survival rates.
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