Piezo1 is a mechanosensitive ion channel that converts mechanical stimuli into electrochemical signals.
Piezo1 protein is a mechanosensitive ion channel that allows intracellular calcium influx in response to various mechanical signals such as static pressure, shear stress, and membrane stretch and further initiates downstream biological responses. It is critical in various physiological processes, including the development of vasculatures, regulation of red blood cell volume, and sensation of light touch. Piezo1 is also highly expressed in the bone, regulating the differentiation of mesenchymal stem cells and mediating calcium ion influx in osteocytes and osteoblasts.
In a number of cancer types (such as breast, colon, and prostate cancer), studies have found that Piezo1 is often upregulated.
An increase in Piezo1 expression can promote enhanced cell migration and invasive behavior, both of which are critical for cancer spread.
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