OPG production in breast cancer cells has been linked to differences in tumor behavior. Some studies suggest that higher OPG expression might counteract RANKL-mediated bone resorption, potentially reducing the risk of bone metastasis.
Prognosis:
-A protective effect has been proposed in certain contexts—elevated OPG levels might be associated with a lower incidence of bone metastasis.
-In contrast, other reports indicate that high circulating OPG levels may correlate with a poorer overall prognosis. This discrepancy could be influenced by whether OPG is functioning in a paracrine fashion within the tumor microenvironment or as a systemic biomarker.
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