Glycogen
• Many tumors, especially under hypoxic or nutrient-deprived conditions, reprogram their metabolism to store glycogen as an energy reserve.
• Increased glycogen accumulation can serve as a survival mechanism that helps cancer cells endure metabolic stress, which, in turn, may be associated with more aggressive behavior.
• Prognosis:
– In certain cancers (e.g., certain glioblastomas, pancreatic cancers), high intratumoral glycogen content has been associated with adaptation to hypoxia and resistance to therapy.
– Such adaptations often correlate with a poorer prognosis, as the glycogen reservoir helps support tumor progression under adverse conditions.
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