Altered Amino Acid Metabolism in Cancer
• Tumors often reprogram their metabolism to meet the demands of rapid proliferation. This reprogramming includes increased uptake and utilization of certain amino acids (e.g., glutamine, serine, glycine) to support anabolic processes.
Key Amino Acids and Their Roles
• Glutamine:
– High tumor dependency on glutamine catabolism (glutaminolysis) has been linked to aggressive phenotypes and may correlate with poor outcomes.
• Serine and Glycine:
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