GLUT2 is a member of the facilitative glucose transporter family, primarily responsible for the uptake of glucose and other hexoses into cells.
– In cancers like HCC, lower GLUT2 expression sometimes correlates with poorer differentiation and a more aggressive phenotype. As cancer cells shift toward a more glycolytic metabolism, they may rely less on the regulated glucose uptake observed in normal cells, and decreased GLUT2 expression can serve as a marker of this metabolic reprogramming.
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