ATP/AMP ratio, a good indicator of cellular energy charge.
A high ratio signifies energy abundance, whereas a low ratio indicates energy stress.
– Cancer cells often shift their metabolism toward glycolysis even in the presence of oxygen, a phenomenon that can lead to abnormal ATP/AMP ratios.
– An increased reliance on glycolysis may lead to a lower ATP production efficiency compared to oxidative phosphorylation, potentially lowering the ATP/AMP ratio despite high rates of glucose metabolism.
• Activation of Energy-Sensing Pathways
– A decreased ATP/AMP ratio activates AMPK, which in turn can inhibit anabolic pathways (e.g., mTOR signaling) that promote cell growth.
(Will delete Record if Target field = "Delete") Home