The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors. The Apc protein is known to interact with several other proteins involved in signal transduction pathways, which regulate cell growth and differentiation.The Apc gene plays a key role in maintaining the integrity of the intestinal epithelium. It functions as a tumor suppressor by inhibiting the abnormal growth of cells and promoting their differentiation. Additionally, this gene helps regulate cell adhesion and migration, ensuring the proper development and function of organs and tissues.The Apc gene acts as a tumor suppressor by regulating the Wnt signaling pathway, which is essential for cell proliferation, differentiation, and self-renewal.
The loss of APC function can lead to dysregulation of the Wnt signaling pathway, contributing to tumorigenesis in various tissues.
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