Sodium-Glucose Cotransporters (SGLTs) primarily functions in the uptake of glucose in a sodium-dependent manner—distinct from the facilitative glucose transporters (GLUTs).
• SGLTs (notably SGLT1 and SGLT2) facilitate active glucose uptake, which is especially important in tissues where glucose levels are low or where rapid uptake is needed.
– Some studies have observed overexpression of SGLT1 in certain tumor types, including pancreatic, prostate, and colorectal cancers.
– SGLT1 expression in tumors may correlate with aggressive growth behavior as it supports increased glucose uptake in environments where GLUT activity might be insufficient.
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