Chloride ion channels and transporters encompass a diverse family of proteins that help regulate membrane potential, cell volume, and intracellular pH.
-Chloride channels facilitate the movement of chloride ions across cell membranes, contributing to processes such as electrical signaling, regulation of cell volume, and maintenance of intracellular pH.
-They include several families and subtypes, such as the CLC family, volume-regulated anion channels (VRACs), and chloride intracellular channel (CLIC) proteins.
-These channels are involved in cell-cycle regulation, apoptosis, and migration—all processes that can influence tumor growth and metastasis.
-Members of the CLC family (e.g., CLC-3) have been reported to be overexpressed in certain cancers like gliomas, breast cancer, and prostate cancer, where they may contribute to enhanced cellular proliferation and invasiveness.
-Chloride intracellular channel proteins (e.g., CLIC1) have been found to have increased expression in cancers including colorectal, lung, and ovarian carcinomas. Elevated levels of CLIC1, for instance, have been linked to increased tumor aggressiveness.
(Will delete Record if Target field = "Delete") Home