– Some studies have reported upregulated expression of certain GABA receptor subunits (e.g., GABA_A receptor subunits) in breast tumors.
– Increased expression has been associated with enhanced cell proliferation and migration, with some reports linking this to a poorer prognosis.
-GABAergic transmission is deficient in anxiety29.
-Neurons expressing GABAA α1 receptors can mediate sedation,
-while those expressing GABAA α2 receptors mediate anxiolytic.
-In addition, extra-synaptic GABAA α5 receptors can also regulate the activity of hippocampal pyramidal cells, thereby affecting associative temporal and spatial memory
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