Tumor cells display a peculiar “methionine dependency” (i.e. an increased need for exogenous methionine), and many enzymes in methionine metabolism are dysregulated in malignancy.
MAT1A,– Primarily expressed in adult liver.
-Decreased MAT1A expression or loss of MAT1A activity is associated with reduced production of S‐adenosylmethionine (SAM) and can contribute to malignant transformation.
MAT2A
-Elevated MAT2A expression is often correlated with enhanced proliferation and a worse prognosis, given its role in maintaining SAM levels in rapidly dividing tumor cells.
-In cancers outside the liver, upregulation of MAT2A and methionine transporters (along with downstream effects on methylation) signify aggressive behavior and may be used as prognostic indicators.
May be desirable to reduce Methionine in diet, and/or use AKBA to help reduce it, before chemo.
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