Peroxiredoxin 4 (PRDX4) is one of the members of the peroxiredoxin family of antioxidant enzymes. It plays a key role in reducing hydrogen peroxide and other peroxides, thereby contributing to the maintenance of the intracellular redox balance. In addition to its antioxidant function, PRDX4 is located in the endoplasmic reticulum (and can be secreted), which adds complexity to its role in cellular homeostasis, stress responses, and cancer biology.
– Several studies have reported that PRDX4 is overexpressed in various cancers, including lung, breast, prostate, and gastrointestinal cancers.
– In some cases, increased PRDX4 levels are thought to reflect a cellular adaptation to elevated oxidative stress in the tumor microenvironment.
– High PRDX4 expression has been observed to correlate with more aggressive tumor phenotypes in particular cancer types. This may be due to its role in protecting cancer cells from oxidative damage, thereby supporting cell survival and growth under stress conditions.
– In some studies, increased PRDX4 has been linked to enhanced tumor progression, metastasis, and resistance to therapy.
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