FOSB—and, more broadly, related AP‐1 family members—in various cancers and their prognostic implications. Keep in mind that:
• The AP‐1 complex is composed of Fos (including FOSB, c‐Fos, Fra-1, Fra-2) and Jun family proteins, and the prognostic role of any one component (like FOSB) may be context‐ and cancer‐type–dependent.
• In many cases, altered expression (up‐ or down‐regulation) of these proteins has been correlated with tumor progression, metastasis, or response to treatment.
-Where lower levels might be associated with poorer prognosis.
• Some reports indicate that decreased expression of certain AP‐1 proteins (or an imbalance in the complex subunits, including FOSB) may be linked to advanced tumor stages and a poorer outcome.
(Will delete Record if Target field = "Delete") Home