p66Shc is one of three isoforms encoded by the ShcA gene and is well known for its roles in oxidative stress response, apoptosis, and cellular metabolism.
• Some studies have revealed that altered p66Shc expression is associated with changes in oxidative stress signaling.
• Elevated p66Shc activity in certain contexts has been linked to enhanced reactive oxygen species (ROS) production, which may promote tumor progression.
• However, the exact relationship is complex; in some research, higher p66Shc levels have been associated with increased cancer cell apoptosis and a better prognosis, while in other studies a pro-oxidative environment may favor tumor aggressiveness.
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