GSDME‐N fragment (the N‐terminal domain of Gasdermin E)
• GSDME (Gasdermin E) is a member of the gasdermin family and is cleaved by caspase‐3 during apoptosis. This cleavage releases the N‐terminal fragment (GSDME‐N), which can form pores in the cell membrane, inducing pyroptosis—a proinflammatory form of programmed cell death.
• Some studies have found that high levels of GSDME expression, which can lead to increased GSDME‐N formation upon cleavage, correlate with enhanced pyroptosis in tumor cells.
• In select breast cancer cohorts, increased pyroptosis may contribute to a more robust local immune response, potentially correlating with improved prognosis.
- Formation of the GSDME‐N fragment and its associated induction of pyroptosis might, in some contexts, favor a more robust anti‐tumor immune response and potentially better clinical outcomes.
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