Trx2 is an essential component of the mitochondrial thioredoxin system, working closely with thioredoxin reductase 2 (TrxR2) to reduce oxidized proteins and protect cells from oxidative stress.
- Mitochondrial thioredoxin (TRX-2).
• By preserving mitochondrial integrity and regulating reactive oxygen species (ROS) levels, Trx2 contributes to cell survival, apoptosis regulation, and metabolic adaptation—all of which are critical in cancer biology.
• Elevated levels of Trx2 may protect tumor cells against oxidative damage, potentially contributing to chemoresistance.
- Overexpression of Trx2 might be associated with more aggressive phenotypes and poorer clinical outcomes, although further studies are needed for definitive prognostic conclusions.
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