PARKIN (also known as PARK2) is an E3 ubiquitin ligase that plays a crucial role in mitochondrial quality control, cell cycle regulation, and apoptosis. Although PARKIN is best known for its involvement in Parkinson’s disease, an increasing number of studies have investigated its role in cancer.
-PARKIN is recruited to damaged mitochondria, which are often sources of elevated ROS due to impaired electron transport chains.
-By targeting dysfunctional mitochondria for autophagic degradation (mitophagy), PARKIN helps to mitigate excessive ROS production, preserving cellular redox balance.
-Reduced PARKIN expression generally correlates with more aggressive disease and worse prognosis in various cancers, including breast, lung, colorectal, liver, and pancreatic cancers.
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