BMAL1 (Brain and Muscle ARNT-Like 1), also known as ARNTL, is a core component of the circadian clock machinery. It regulates daily rhythmicity in gene expression, metabolism, cell cycle, and DNA repair mechanisms.
-BMAL1 is emerging as an important factor in cancer biology through its regulation of circadian rhythms, metabolism, and the cell cycle. Altered BMAL1 expression or disrupted oscillatory patterns have been associated with more aggressive tumors and poorer prognosis in several cancer types, including breast, colorectal, lung, and liver cancers.
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