UHRF1 (Ubiquitin-like with PHD and RING Finger domains 1) is an epigenetic regulator known to be overexpressed in several cancer types. Its altered expression is often associated with poor prognosis.
-UHRF1 is critical for the maintenance of DNA methylation during replication by recruiting DNA methyltransferase 1 (DNMT1) to hemimethylated DNA.
-Evidence suggests that UHRF1 can negatively regulate p53, a key tumor suppressor protein.
-Several studies have linked high UHRF1 expression with the activation of the PI3K/AKT pathway.
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