Adequate intracellular vitamin C can contribute to the hydroxylation and subsequent degradation of HIF-1α. Elevated HIF-1α is often associated with aggressive tumor behavior and poor prognosis.
Ascorbate Transporters
• SVCT2 (Sodium-Dependent Vitamin C Transporter 2)
– Role: Mediates the uptake of ascorbate into cells.
• GLUT Transporters (e.g., GLUT1)
– Role: While primarily known for transporting glucose, certain GLUT family members (especially GLUT1) also facilitate the uptake of the oxidized form of vitamin C (dehydroascorbate).
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