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tid Target Cancers General Effect on Target
Name
Source
Type

Tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene)

• TrkB is a high‐affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).

• It has been implicated in promoting cell survival, proliferation, migration, and resistance to apoptosis.

• In several cancer types, increased TrkB expression has been associated with enhanced tumor aggressiveness and metastasis.




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