ATF3 (Activating Transcription Factor 3) is a stress‐responsive transcription factor that is frequently induced by various cellular stresses, including DNA damage, oxidative stress, and inflammatory signals.
-Several studies have shown that ATF3 is upregulated in response to cellular stress in breast cancers.
-Increased ATF3 expression has been associated with reduced cell proliferation and invasiveness, suggesting a tumor-suppressive role.
• In some cancers and contexts, elevated ATF3 is linked with apoptosis induction and a favorable prognosis, acting as a tumor suppressor.
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