Paraoxonases refer to a family of enzymes—primarily PON1, PON2, and PON3—that are involved in the detoxification of oxidized lipids and the metabolism of various xenobiotics. Their roles in modulating oxidative stress and inflammation have attracted attention in cancer research.
-Upregulation in Some Tumors: In certain cancer types, elevated expression of paraoxonase enzymes may occur as an adaptive response to increased oxidative stress. For instance, some tumors demonstrate increased levels of PON2, which could help protect cancer cells from oxidative damage.
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