PIP3 is a key lipid second messenger that plays a central role in the PI3K/AKT signaling pathway.
– Increased PIP3 levels are a hallmark of cancers characterized by PI3K pathway activation.
– Mutations or amplifications in PI3K subunits and loss of PTEN function often result in sustained PIP3 production, thereby driving oncogenic processes.
– Elevated PIP3 signaling contributes to increased cell proliferation, survival, metabolic reprogramming, and metastatic potential.
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