SXR (Steroid and Xenobiotic Receptor, also known as Pregnane X Receptor, PXR).
-SXR/PXR is a nuclear receptor that is primarily known for its role in detecting and mediating the metabolism and clearance of xenobiotics, drugs, and endogenous compounds.
- Since SXR/PXR regulates drug-metabolizing enzymes and transporters, overexpression in tumor cells may lead to increased metabolism and clearance of anticancer drugs, potentially contributing to chemoresistance.
– Some studies suggest that high SXR/PXR expression might be linked to more aggressive tumor behavior in certain cancers, such as breast, prostate, and gastrointestinal cancers, as it can alter cellular metabolic states and modulate survival pathways.
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