TPI (Triosephosphate Isomerase)
– TPI is a key glycolytic enzyme that catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).
– By facilitating glycolysis, TPI plays a crucial role in energy production and metabolic flux in cells.
– Enhanced Glycolytic Activity: Elevated TPI levels can correlate with increased glycolytic flux, supporting the energetic and biosynthetic demands of rapidly proliferating tumor cells.
– Clinical Outcomes: Several studies have suggested that overexpression of TPI may be associated with more aggressive tumor behavior and poorer patient prognosis, though the specific prognostic value can be context- and cancer type–dependent.
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