GPI (Glucose-6-Phosphate Isomerase)
– GPI catalyzes the reversible interconversion of glucose-6-phosphate and fructose-6-phosphate, a critical step in glycolysis and gluconeogenesis.
GPI can contribute to the enhanced glycolytic activity observed in many tumors.
– Tumor Aggressiveness: Elevated levels of GPI (both intracellular and secreted forms) have been correlated with enhanced invasiveness and metastatic potential, particularly in cancers such as breast, lung, and gastric cancers.
– Poor Outcomes: Increased GPI may serve as a marker for aggressive tumor phenotypes and is often associated with poorer clinical outcomes. In some studies, high serum levels of GPI/AMF have been proposed as indicative of advanced disease and a worse prognosis.
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