Talin is a cytoskeletal protein that plays a central role in linking integrins to the actin cytoskeleton. Two major isoforms exist—talin-1 and talin-2.
-Talin serves as a key mediator of integrin activation and cytoskeletal organization, functions that underpin its role in regulating cell adhesion, migration, and invasion.
-In several cancers—including breast, prostate, and colorectal cancers—elevated expression of talin (most notably talin-1) has been associated with more aggressive tumor behavior, increased metastatic potential, and poorer clinical outcomes.
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