PDHA1 (Pyruvate Dehydrogenase E1 Alpha 1 Subunit)
– PDHA1 encodes the alpha subunit of the pyruvate dehydrogenase (PDH) complex, which is crucial for converting pyruvate into acetyl-CoA.
– This step links glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, making PDHA1 a key regulator of cellular energy metabolism.
– Proper PDHA1 function supports oxidative metabolism, whereas impaired activity can shift metabolism toward a glycolytic phenotype (commonly referred to as the Warburg effect) in cancer cells.
-Low PDHA1 expression or activity may be associated with enhanced glycolysis, leading to increased tumor proliferation and survival under stress.
– Clinical Outcome: In several cancer types, reduced PDHA1 levels (or increased PDH inhibition) have been correlated with more aggressive disease and poorer outcomes, suggesting a potential prognostic role.
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