-Vasculogenic mimicry refers to the process by which aggressive tumor cells form vascular channel–like structures independently of endothelial cells.
-Unlike classical angiogenesis where new blood vessels develop from preexisting vasculature, VM involves tumor cell plasticity that allows cancer cells to create perfusable networks resembling blood vessels.
-This phenomenon is often observed in highly aggressive and metastatic tumors, reflecting the ability of these cells to adapt to hypoxia and other microenvironmental stresses.
-Tumor regions with low oxygen levels often stimulate VM formation as an adaptive response. Hypoxia promotes a switch in cellular metabolism and gene expression that supports both angiogenesis and vasculogenic mimicry, thus ensuring continued nutrient supply and waste removal.
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