Netrins genes encode a family of secreted and membrane‐associated proteins that function as chemotropic guidance signals for directing cell and axon migration throughout nervous system development.
Netrin-1 is upregulated in a large fraction of cancers.
The expression of Netrin-1 is markedly reduced or absent in ~50% of brain tumors and prostate cancer, while it is overexpressed in many other cancers.
Netrin family consists primarily of secreted proteins (e.g., Netrin‑1, Netrin‑4) and their receptors (such as DCC [Deleted in Colorectal Cancer] and UNC5 homologues) that guide axonal migration and cell positioning during development. Their roles in cancer are complex and context‑dependent, with some family members acting as tumor promoters and others behaving in a tumor‑suppressive manner.
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