Guanine nucleotide-binding proteins, commonly known as G proteins, play a crucial role in cellular signaling pathways. The Gq class of G proteins, which includes the alpha subunit Gαq, is involved in various physiological processes, including the regulation of phospholipase C (PLC) activity, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These second messengers are important for calcium signaling and activating protein kGαq signaling can promote cell proliferation and survival through various pathways, including the activation of the MAPK/ERK pathway. Dysregulation of these pathways can lead to uncontrolled cell growth, a hallmark of cancer.
inase C (PKC), which can influence cell growth, differentiation, and survival.
GNA11 expression and its associated signaling pathways are often altered in various cancers, and these changes can be linked to poorer prognosis due to their role in promoting tumor growth and survival.
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