View: by Target 12LOX, 12‐lipoxygenase14-3-3 proteins, 14-3-3 proteins4-HNE, 4‑Hydroxynonenal4E-BP1, eukaryotic translation initiation factor 45HT, Serotonin5LO, 5-lipoxygenase (5-LO)67LR, 67-kDa laminin receptor6PGD, 6-phosphogluconate dehydrogenaseABC, ABC transporterABCG2, ATP-binding cassette sub-family G member 2ABL1, Tyrosine-protein kinase ABL1Ac-histone H3, Acetylated Histone H3ACAA1, Acetyl-CoA Acyltransferase 1ACC, Acetyl-CoA CarboxylaseACC-α, Acetyl-CoA Carboxylase alphaACC1, acetyl‐CoA carboxylase 1Acetyl-CoA, Acetyl-CoAAch, AcetylcholineAChE, acetylcholinesteraseACLY, ATP citrate lyaseACOX1, Acyl-CoA Oxidase 1ACSL1, Acyl-CoA Synthetase Long-Chain Family MembeACSL4, Acyl-CoA Synthetase Long-Chain Family MembeACSL5, (Acyl-CoA Synthetase Long Chain Family MembACSS2, Acyl-CoA Synthetase Short Chain Family MembACTA2, Actin Alpha Cardiac Muscle 2ACVR1B, activin A receptor, type IBADAM17, A Disintegrin and Metalloprotease 17adiP, adiponectinADP:ATP, ADP/ATP ratioAEG1, Astrocyte Elevated Gene-1AFP, α-fetal proteinAGRN, agrinAhR, aryl hydrocarbon receptorAIF, Apoptosis-Inducing FactorAIM2, Absent In Melanoma 2AKR1C2, Aldo-keto reductase family 1 member C2Akt, PKB-Protein kinase BAKT1, v-akt murine thymoma viral oncogene homolog Akt2, RAC-beta serine/threonine-protein kinaseALAT, ALT, alanine aminotransferaseAlbumin, AlbuminALC, absolute lymphocyte countALDH, Aldehyde DehydrogenaseALDH1A1, Aldehyde Dehydrogenase 1A1ALDOA, Aldolase AALDOAiso2, fructose-bisphosphate aldolase A isoforAlix/AIP‑1, Alix (ALG‑2–interacting protein ALK, anaplastic lymphoma receptor tyrosine kinaseALP, Alkaline PhosphataseAMACR, alpha-methylacyl-CoA racemaseAminoA, Amino AcidsAMP, Adenosine MonophosphateAMPK, adenosine monophosphate-activated protein kiAMPKα, AMP-activated protein kinaseangioG, angiogenesisangioS, angiostatinannexin II, ANXA2AntiAg, Antiplatelet aggregationAntiAge, Anti-agingAntiCan, Anticancer EffectantiOx, anti-oxidant activitiesAntiTum, AntiTumorANXA7, annexin A7AP-1, Activator protein 1APA, autophagosome accumulationAPAF1, Apoptotic Protease Activating Factor 1APC, adenomatous polyposis coliApoptosis, ApoptosisAPP, amyloid-beta precursor proteinAppetite, AppetiteAQPs, AquaporinsAR, androgen receptorAR-FL, full-length androgen receptorAR-V7, androgen receptor splice variant 7ARE/EpRE, electrophile response element/antioxidanARG, Arginases ARG1/2ARID1A, AT rich interactive domain 1A (SWI-like)ARID1B, AT rich interactive domain 1B (SWI1-like)ARID2, AT rich interactive domain 2 (ARID, RFX-likARNT, aryl hydrocarbon receptor nuclear translocatASC, Apoptosis-associated Speck-like protein contaascitic, ascitic fluidASCT2, ASCT2 glutamine transporterASK1, Apoptosis Signal-regulating Kinase 1aSmase, Acid SphingomyelinaseAST, Aspartate AminotransferaseASXL1, additional sex combs like 1 (Drosophila)ATF2, Activating Transcription Factor 2ATF3, Activating Transcription Factor 3ATF4, Activating Transcription Factor 4ATF6, Activating Transcription Factor 6ATFs, activating transcription factorATG3, Autophagy-related 3ATG5, Autophagy-related 5ATG7, ATG7ATM, similar to Serine-protein kinase ATM (Ataxia ATP, Adenosine triphosphateATP:AMP, ATP:AMP ratioATPase, ATPase (V‐ATPase)ATR, Ataxia-Telangiectasia and Rad3-relatedATRX, alpha thalassemia/mental retardation syndromautolysosome, autolysosomeautoS, autoschizisAVOs, Acidic vesicular organellesAXIN1, Axis inhibition protein 1Axin2, AXL, AnexelektoAβ, Aβ aggregationB2M, beta-2-microglobulinBACE, β-site APP-cleaving enzymeBACH1, BTB and CNC homology 1Bacteria, Effect on BacteriaBAD, BCL2 associated agonist of cell deathBak, BAK or BAK1BAP1, BRCA1 associated protein-1 (ubiquitin carboxBAX, Apoptosis regulator BAXBax:Bcl2, Bax:Bcl2 ratioBBB, Blood-Brain BarrierBCAP, B cell adaptor for phosphatidylinositol 3(PIBChE, butyrylcholinesteraseBcl-2, B-cell CLL/lymphoma 2Bcl-xL, Bcl-xLBCOR, BCL6 co-repressorBCR, Breakpoint Cluster RegionBCR-ABL, BCR-ABLBeclin-1, Beclin-1Bfl-1, Bfl-1 (A1)BG, Blood GlucoseBID, BH3 interacting-domain death agonistBIM, BIM protein (BCL-2 Interacting Mediator of ceBioAv, bioavailabilityBioEnh, bioenhancerBMAL1, ARNTLBMD, bone mineral densityBMI1, B cell-specific Moloney murine leukemia viruBMP2, Bone Morphogenetic Protein 2BMP3, Bone Morphogenetic Protein 3BMPs, Bone morphogenetic proteinBNIP3, BCL2/adenovirus E1B interacting protein 3BNP, Brain Natriuretic PeptideBOK, Bcl-2-related ovarian killerBowelM, Regular Bowel MovementBP, Blood PressureBRAF, v-raf murine sarcoma viral oncogene homolog BRCA1, BReast CAncer gene 1BRCA2, BReast CAncer gene 2breath, breathing abilityBRG1, Brahma-related gene 1Brk/PTK6, Breast Tumor Kinase/Protein Tyrosine KinBTG3, B-cell translocation gene 3BUN, blood urea nitrogenCA, Carbonic anhydrasesCa+2, Calcium Ion Ca+2CA125, CA125cachexia, cachexiaCAFs/TAFs, cancer/tumor-associated fibroblastCAIX, Carbonic Anhydrase IXcal2, calpain-2Calcium, Calcium mineralizationCaMKII , Calcium/Calmodulin-dependent Protein KincAMP, cyclic adenosine monophosphatecarcinogenesis, carcinogenesisCARD11, caspase recruitment domain family, member cardioP, cardioProtectiveCardioT, CardiotoxicityCarnA, Carnitine AcyltransferaseCartilage, CartilageCasp, caspaseCasp1, Caspase-1Casp10, cysteine-aspartic protease 10Casp12, Caspase-12Casp2, caspase-2Casp3, CPP32, Cysteinyl aspartate specific proteinCasp6, Caspase-6Casp7, Caspase-7Casp8, CASP8, caspase 8, apoptosis-related cysteinCasp9, Caspase-9Catalase, CatalaseCav1, Caveolin-1CBL, Casitas B-lineage LymphomaCBP, CREB-binding proteinCC(CDKs/cyclins), Cell cycle (CDKs/cyclins)CC/Apoptosis, Cell Cycle / ApoptosisCCDC150, CCDC150, Coiled-coil domain-containing (CCCL20, Chemokine [C-C motif] ligand 20CCR7, C-C chemokine receptor type 7CD11b, CD11bCD133, prominin-1CD14, CD14CD24, CD24CD25+, IL-2Rα interleukin-2 receptor alphaCD31, platelet endothelial cell adhesion molecule-CD34, CD34 transmembrane phosphoglycoprotein proteCD38, CD38 proteinCD4+, CD4+ T CellsCD44, CD44CD69, CD69CD8+, CD8+ T cellCDC16, Cell Division Cycle 16CDC2, cell division cycle 2cDC2, type 2 conventional dendritic cellCDC25, Cell Division Cycle 25Cdc42, Cdc42cdc2CDC7, Cell Division Cycle 7CDC73, cell division cycle 73, Paf1/RNA polymeraseCDH1, cadherin 1, type 1, E-cadherin (epithelial)CDK1, Cyclin-dependent kinase 1CDK1/2/5/9, Cyclin-dependent kinases (CDKs)CDK2, Cyclin-dependent kinase 2CDK4, Cyclin-dependent kinase 4CDK4/6, CDK4/6CDK6, Cyclin-dependent kinase 6CDK8, cyclin‐dependent kinase 8CDKN1C, cyclin-dependent kinase (CDK) inhibitors oCDKN2A, cyclin-dependent kinase inhibitor 2A (melaCDX2, Caudal-type homeobox 2CEA, Carcinoembryonic antigenCEBPA, CCAAT/enhancer binding protein (C/EBP), alpCEBPB, CCAAT/enhancer‐binding protein betacellD, cell DeathCellMemb, Cellular Membrane alterationscellSen, cellular senescenceCentClus, Centrosome clusteringCeru, ceruloplasmincFLIP, cellular FLICE-like inhibitory proteincFos, cellular FosChAT, Choline acetyltransferaseChemChap, chemical chaperoneschemoP, ChemoProtectivechemoR, chemoresistanceChemoSen, chemo-sensitizationChemoSideEff, Side Effects of ChemoCHK1, Checkpoint Kinase 1Chk2, Checkpoint Kinase 2Chl, chlorideCholine, Cholinecholinesterase, cholinesteraseCholMet, Cholesterol metabolitesCholSyn, Cholesterol synthesisCHOP, GADD153ChrMod, Chromatin modificationCIC, capicua homolog (Drosophila)CIP2A, Cancerous Inhibitor of Protein Phosphatase circ-PRKCA, circular RNA PRKCAcitrate, citrate levelscJun, cellular Transcription factor JunCK2, Casein Kinase 2CLDN1, claudin-1CLDN2, claudin-2CLDN3, claudin‑3CLDN5, Claudin-5CLP, bone marrow common lymphoid progenitor cellscMET, cellular hepatocyte growth factor receptorcMYB, c-MYBcMyc, cellular-MYC oncogeneCofilin, Cofilincognitive, cognitiveCOL1, Collagen ICOL1A1, Collagen Type I Alpha 1 ChainCOL2A1, COL2A1COL3A1, collagen3aCOL4, Collagen IV alpha chainCOL9A3, COL9A3COMP, Cartilage Oligomeric Matrix ProteincompI, mitochondrial complex-IcompIII, Mitochondrial complex IIICOMT, catechol-O-methyl transferaseCopper, CopperCoQ10, coenzyme Q10cortisol, cortisolCOX1, COX-1COX2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protcPLA2, cytosolic phospholipase A2CPT1A, Carnitine Palmitoyltransferase 1ACR3, Complement Receptor Type 3creat, creatinineCREB, cAMP Response Element Binding ProteinCREB2, cAMP response element‐binding protein 2CREBBP, CREB binding proteinCRLF2, cytokine receptor-like factor 2CRM, Calorie restriction mimetics (CRMs)CRM1, Nuclear exporter CRM1CRP, C-reactive proteinCRT, calreticulinCSCs, Cancer Stem CellsCSCsMark, Cancer Stem Cell MarkersCSF1R, colony stimulating factor 1 receptorCSR1, Cellular stress response 1cSrc, cellular Proto-oncogene tyrosine-protein kinCT-I, Chymotrypsin-like (CT-l) activityCTC, Circulating-Tumour-CellsCTGF, Connective Tissue Growth FactorCTLA-4, Cytotoxic T-Lymphocyte Antigen‑4CTNNB1, catenin (cadherin-associated protein), betCTR1, Copper Transporter 1CUL4B, Cullin 4BCupro, CuproptosisCXCc, CXC chemokine familyCXCL1, CXCL1CXCL12, SDF–1CXCL9, CXCL9CXCR2, CXCR2CXCR4, Chemokine Receptor Type 4Cyc, CyclincycA1, cyclin A1CycB, Cyclin BcycD1, cyclin D1 pathwayCycD3, Cyclin D3cycE, Cyclin EcycE1, cyclin E1cycF, CCNF cyclin FCYFRA21-1, cytokeratin 19 fragmentsCYLD, cylindromatosis (turban tumor syndrome)CYP11A1, CYP11A1CYP17A1, cytochrome P450 CYP17A1CYP19, aromataseCYP1A1, Cytochrome P450 1A1CYP1A2, CYP1A2CYP1B1, CYP27B1, CYP27B1CYP2C6, CYP2C6CYP2C9, CYP2C9CYP2D1, CYP2D1CYP2E1, cytochrome P450 2E1 (CYP2E1)CYP3A2, CYP3A2CYP3A4, CYP3A4Cyt‑c, cyt-c Release into CytosolcytoP, cytoprotectioncytoP450, cytochrome P450 (CYP)DAXX, death-domain associated proteinDCells, dendritic CellsDcr, Disturbed circadian rhythmsdecorin, decorinDFF45, DNA Fragmentation Factor 45 GeneDGAT1, Diacylglycerol O-acyltransferase 1DHCR24, 24-Dehydrocholesterol ReductaseDHT, dihydrotestosterone levelDiablo, DiabloDiff, differentiationDJ-1, DJ-1DLC1, deleted in liver cancer 1DLEU1, Deleted in Lymphocytic Leukemia 1DNA-PK, DNA-dependent protein kinaseDNAdam, DNA damageDNAdamC, DNA damage controlDNArepair, DNA repairDNMT1, DNA (cytosine-5-)-methyltransferase 1DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alphDNMTs, DNA methyltransferaseDose, DosageDPPH, 2,2-diphenyl-1-picrylhydrazylDR4, Death Receptor 4DR5, Death receptor 5E-cadherin, E-cadherinE-sel, E-selectinE2Fs, E2F family of transcription factorsE6, E6E7, E7ECAR, Extracellular Acidification RateECM/TCF, Endothelial cell migration/tip cell formaEF-1α, elongation factor 1 alphaEFEMP, EGF-containing fibulin-like extracellular meff, efficacyEGF, Epidermal Growth Factor expressionEGFR, Epidermal Growth Factor ReceptorEGR1, Early Growth Response 1EGR4, Early Growth Response 4eIF2α, Eukaryotic translation initiation factor 2EIF4E, eukaryotic translation initiation factor 4EEifp, Elevated interstitial fluid pressureElvol3, ELOVL fatty acid elongase 3EM, epithelial markersEMMPRIN, Extracellular Matrix Metalloproteinase InEMT, Epithelial-Mesenchymal TransitionEndoglin, CD105Endon, endonucleaseENO1, α-EnolaseENO2, Enolase 2eNOS, endothelial Nitric Oxide SynthaseENOX, enolaseENOX2, NADH oxidasesEP2, Prostaglandin E2 receptor 2EP300, E1A binding protein p300EP4, Prostaglandin E2 receptor 4EpCAM, epithelial Cell Adhesion MoleculeEphB4, tyrosine kinase EphB4EPR, enhanced permeability and retention (EPR) effER Stress, endoplasmic reticulum (ER) stress signaER-α36, estrogen receptor alpha (ERα) protein vaER(estro), Estrogen receptorERCC1, Excision Repair Cross Complementation groupERK, ERK signalingERK5, extracellular signal-regulated kinase 5ERS, Endoplasmic reticulum stressERα, Estrogen Receptor alphaERβ, Estrogen receptor beta also known as NR3A2Estro, EstrogenEstroRS, Estrogen receptor signalingEZH2, enhancer of zeste homolog 2 (Drosophila)F-actin, fibrous actinFABP4, Fatty acid-binding proteins 4FADD, FADDFAK, FAK signalingFAM123B, family with sequence similarity 123BFAM72A, FAM72AFAO, Fatty Acid OxidationFap1, PTPN13Fas, Fas Death receptorfascin, fascinFasL, Fas ligandFASN, Fatty acid synthaseFBI-1, FBI‑1 (Pokemon/ZBTB7A)FBP1, fructose-1,6-bisphosphatase 1FBPase, Fructose-1,6-BisphosphataseFBXW7, F-box and WD repeat domain containing 7FDG, F-FDGFenton, Fenton ReactionFerritin, SF serum FerritinFerroptosis, FerroptosisFGF, Fibroblast growth factorsFGF21, FGF21FGFR1, Fibroblast Growth Factor Receptor 1FGFR2, fibroblast growth factor receptor 2FGFR3, fibroblast growth factor receptor 3Fibronectin, FibronectinFibrosis, FibrosisFKBP5, FK506 binding protein 51FLRT2, FLRT2 geneFLT3, fms-related tyrosine kinase 3FLT4, Fms-related tyrosine kinase 4FOSB, FOSBFOSL1, FOSL1 (FRA-1)FOXD3, FOXD3FOXL2, forkhead box L2Foxm1, FOXM1 transcription factorFOXO, Forkhead box OFOXO1, Forkhead box O1FOXO3, Forkhead Box O3FOXO4, Forkhead box O 4FOXP3, forkhead box P3FoxP3+, Forkhead box P3+frataxin, frataxinFTH1, ferritin heavy chainFTL, ferritin light chainFUBP1, far upstream element (FUSE) binding proteinFurin, FurinG6PD, Glucose-6-phosphate dehydrogenaseG9a, G9aGABA, γ-aminobutyric acidGADD34, Growth Arrest and DNA Damage-inducible proGADD45A, Growth Arrest and DNA Damage-inducible 45Galectin-9, Galectin-9GAPDH, Glyceraldehyde-3-phosphate dehydrogenaseGATA1, GATA binding protein 1 (globin transcriptioGATA2, GATA binding protein 2GATA3, GATA binding protein 3GCLC, Glutamate-Cysteine Ligase, Catalytic SubunitGCLM, Glutamate-Cysteine Ligase Modifier SubunitGDF15, Growth differentiation factor 15GDH, Glutamate dehydrogenaseGFR, glomerular filtration rateGIT1, GIT-1 geneGli, GLIGli1, glioma-associated oncogene homolog 1GLI2, GLI2GLI3, GLI3GLO-I, glyoxalase IGLS, glutaminaseglucoNG, gluconeogenesisglucose, glucoseGlucoseCon, Glucose Consumptionglut, glutamineGLUT1, Glucose Transporter 1GLUT2, Glucose Transporter 2GLUT3, GLUT3GLUT4, Glucose Transporter 4GlutaM, GlutaminolysisGlutMet, Glutamine metabolismglyC, glycogenGlycolysis, GlycolysisGM-CSF, Granulocyte-macrophage colony-stimulating GNA11/Gαq, guanine nucleotide binding protein (G GNAQ, guanine nucleotide binding protein (G proteiGNAS, GNAS complex locusGNLY, GranulysinGnT-V, N-acetylglucosaminyltransferase-VGP1BB, glycoprotein Ib beta subunit geneGPI, Glucose-6-Phosphate IsomeraseGPx, Glutathione peroxidasesGPx1, Glutathione PeroxidaseGPx3, Glutathione Peroxidase 3GPx4, Glutathione Peroxidase 4GPx8, Glutathione Peroxidase 8GR, glucocorticoid receptorsGranA, granzyme AGranB, Granzyme BGREM1, Gremlin1GRP58, GRP58/ERp57GRP78/BiP, HSPA5GRP94, Glucose-Regulated Protein 94GS3Kβ, Glycogen Synthase Kinase 3 BetaGSDMC, Gasdermin CGSDMD, gasdermin DGSDME, gasdermin EGSDME-N, N‐terminal domain of Gasdermin EGSH, GlutathioneGSH/GSSG, GSH/GSSG ratioGSK‐3β, Glycogen synthase kinase (GSK)3βGSR, Glutathione ReductaseGSS, Glutathione SynthetaseGSSG, oxidized glutathioneGSTA1, Glutathione S-Transferase A1GSTP1/GSTπ, Glutathione S-transferase pi 1GSTs, Glutathione S-transferasesGSTZ1, Glutathione S-transferase zeta 1GTPBP4, GTP-binding protein 4GutMicro, Gut MicrobiotaH19, H19 long non-coding RNA (lncRNA)H2O2, Hydrogen peroxide (H2O2)H2S, hydrogen sulfideH3, Histone 3H3F3A, H3F3AH3K18, Histone 3 Lysine 18H3K27ac, histone H3 lysine 27 acetylationH4, Histone 4Half-Life, Half-LifeHATs, histone acetyltransferasesHbA1c, hemoglobin A1cHCAR1, Hydroxycarboxylic acid receptor 1HDAC, Histone deacetylasesHDAC1, Histone Deacetylase 1HDAC10, HDAC10HDAC11, Histone Deacetylase 11HDAC2, Histone Deacetylase 2HDAC3, Histone Deacetylase 3HDAC4, Histone deacetylasesHDAC6, HDAC6HDAC8, Histone deacetylase 8HDL, HDL cholesterolHear, HearingHEC1, highly expressed in cancer 1HemoG, Hemoglobinheparanase, heparan sulfate degrading endoglycosidhepatoP, L,hepatoprotectiveHER2/EBBR2, Human epidermal growth factor receptorHEY1, Hairy/enhancer-of-split related with YRPW moHGF/c-Met, met proto-oncogene (hepatocyte growth fHH, Hedgehog signalingHIF-1, HIF-1 signalingHif1a, HIF1α/HIF1aHIF2a, Hypoxia-Inducible Factor 2 alphaHippo, Hippo signaling pathwayHIST1H3B, histone cluster 1, H3j, H3, H3h, H3g, H3Histones, HistonesHK1, Hexokinase 1HK2, Hexokinase 2HLA, Human Leukocyte Antigen (HLA) moleculesHMG-CoA, 3‐hydroxy-3‐methylglutaryl‐coenzymeHMGB1, High Mobility Group Box 1HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase (HHMTs, Histone methyltransferases (HMTs)HNE, 4-hydroxynonenal (HNE)HNF1A, HNF1 homeobox AhnRNPA1, Heterogeneous nuclear ribonucleoprotein AHO-1, HMOX1HO-2, HO-2homoC, homocysteineHR, Homologous recombinationHRAS, v-Ha-ras Harvey rat sarcoma viral oncogene hHRI, Heme-regulated eIF2α kinasehs-CRP, High-sensitivity C-reactive proteinHsc70, Heat Shock Cognate Protein 70HSD17B4, hydroxysteroid 17-beta dehydrogenase 4HSD3B, HSD3BHSF1, Heat Shock Factor 1HSP27, Heat shock protein 27HSP70/HSPA5, heat shock proteins 70 kilodaltonHSP72, Heat Shock Protein 72HSP90, HSP90HSPs, Heat shock proteinshTERT, human telomerase reverse transcriptasehyperG, hyperglycemiaHypoxia, HypoxiaIAP1, cIAP1, cellular Inhibitor of Apoptosis ProteIAP2, cIAP2, cellular Inhibitor of Apoptosis ProteICAD, inhibitor of caspase-activated DNaseICAM-1, Intercellular Adhesion Molecule 1ICD, immunogenic cell death (ICD)Id1, Inhibitor of DNA binding 1(Inhibitor of DiffeIDH1, isocitrate dehydrogenase 1 (NADP+), solubleIDH2, isocitrate dehydrogenase 2 (NADP+), mitochonIDO, indoleamine 2,3-dioxygenaseIDO1, indoleamine 2, 3-dioxygenase 1IFN-γ, Interferon-γIGF-1, insulin-like growth factor-1IGF-1R, insulin-like growth factor-1 receptorIGF-2, Insulin-like growth factor 2IGFBP1, Insulin-like Growth Factor Binding ProteinIGFBP3, Insulin-Like Growth Factor Binding ProteinIGFBP7, Insulin-like Growth Factor Binding ProteinIGFR, Insulin-like Growth Factor ReceptorIgs, immunoglobulins (IgG and IgM)Ikaros, IkarosIKKα, IκB kinase alpha)IL1, Interleukin-1IL10, Interleukin-10IL12, Interleukin-12IL17, Interleukin-17IL18, Interleukin 18IL1α, interleukin-1 alphaIL1β, interleukin-1 betaIL2, Interleukin-2IL22, Interleukin-22IL23, Interleukin 23IL28, Interleukin-28IL33, Interleukin-33IL4, interleukin 4IL5, Interleukin-5IL6, Interleukin-6IL8, Interleukin-8IL9, Interleukin-9IM, interstitial markersImm, immunostimulatoryIMPDH1, inosine monophosphate dehydrogenase 1IMPDH2, inosine monophosphate dehydrogenase 2importin α/β, importin α/β (karyopherin α andInf, InfectionINF-γ, interferon gammaInflam, inflammationiNOS, Inducible nitric oxide synthaseInsulin, InsulinIP-10/CXCL-10, Interferon-γ(IFN)-inducible proteiIR, Insulin Receptor pathwayIRAK4, interleukin-1 receptor-associated kinase 4IRE1, Inositol-Requiring Enzyme 1IRF3, Interferon Regulatory Factor 3Iron, IronIronCh, Iron ChelatorIRP1, Iron regulatory protein 1ITGA1, Integrin Subunit Alpha 1ITGA11, Integrin α11ITGA5, Integrin alpha 5ITGB1, Integrin beta-1ITGB3, integrin β3ITGB4, Integrin Subunit Beta 4ITGB6, Integrin Subunit Beta 6IκB, IκB kinase(α)JAK, Janus kinasesJAK1, Janus kinase 1JAK2, Janus kinase 2JAK3, Janus kinase 3JAML, Junctional Adhesion Molecule-LikeJNK, c-Jun N-terminal kinase (JNK)Jun, JunJWA, JWA protein or JWA geneK17, Keratin 17KCNQ1OT1, KCNQ1OT1KDM5C, lysine (K)-specific demethylase 5CKDM6A, lysine (K)-specific demethylase 6AKDR/FLK-1, Kinase insert Domain-Containing ReceptoKeap1, Kelch-like ECH-associated protein 1KeyT, KeytonesKi-67, Ki-67 proteinKIF2C, Kinesin Family Member 2CKISS1, KISS1KIT, KITKLF2, Krüppel-like factor 2KLF4, Kruppel-like factor 4KLF5, Krüppel-like factor 5KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogeneL-sel, L‑selectin/CD62Llact/pyru, lactate/pyruvate ratiolactateProd, lactate productionLAMA5, laminin alpha 5LAMB3, Laminin subunit beta-3LAMP1, Lysosome-Associated Membrane Protein 1LAMP2, Lysosome-Associated Membrane Protein 2LAMs, LamininsLAR, lactate receptorLAT, L-Type Amino Acid TransporterLATgene, linker for activation of T cellsLC3‑Ⅱ/LC3‑Ⅰ, ratio of LC3‑Ⅱ/LC3‑ⅠLC3A, Microtubule-associated protein 1 light chainLC3B, microtubule-associated protein 1 light chainLC3B-II, LC3B-IILC3I, Lysosomal-associated membrane protein 2ALC3II, Microtubule-associated protein 1A/1B light LC3s, Autophagosome ProteinsLDH, Lactate DehydrogenaseLDHA, Lactate dehydrogenase ALDHB, Lactate dehydrogenase BLDL, LDL-cholesterolLEF1, Lymphoid enhancer-binding factor 1Let-7, Let-7LGR5, Leucine-rich repeat-containing G-protein couLIF, leukemia inhibitory factorlipid-P, lipid peroxidationlipidDe, Lipid DepositionlipidLev, Lipid LevelslipoGen, lipogenesisLOX1, Lectin-like oxidized low-density lipoproteinLPS, LPSLRP6, Low-density lipoprotein receptor–related pLymphAG, LymphangiogenesislysoM, Lysosome Membrane IntegritylysoMP, lysosomal membrane permeabilizationLysoPr, lysosomal proteolysislysosome, lysosome/lysosomalM1, M1 macrophagesM2 MC, M2 macrophage conversionMacrophages, MacrophagesMAD, MAD proteinsMag, MagnesiumMALAT1, Metastasis Associated Lung Adenocarcinoma MAOA, Monoamine Oxidase AMAP2K1/MEK1, mitogen-activated protein kinase kinaMAP3K1, mitogen-activated protein kinase kinase kiMAPK, mitogen-activated protein kinaseMARK4, Microtubule Affinity-Regulating Kinase 4Maspin, SERPINB5Matr, matriptaseMATs, Methionine AdenosyltransferasesMBD2, Methyl-CpG binding domain protein 2Mcl-1, myeloid cell leukemia 1MCP1, monocyte chemotactic protein-1MCT1, Multiple Copies in T-cell malignancy 1MCT4, Monocarboxylate Transporter 4MCU, mitochondrial calcium uniporterMDA, Serum malondialdehydeMDM2, Double Minute 2 homologMDMX, MDM4MDR1, Multidrug Resistance 1MDSCs, Myeloid-derived suppressor cellsMeCP2, Methyl-CpG-Binding Protein 2MED12, mediator complex subunit 12MEG3, Maternally Expressed Gene 3MEK, Mitogen-Activated Protein Kinase Kinasememory, memoryMEN1, multiple endocrine neoplasia IMET, mesenchymal-epithelial-transitionMets, MetallothioneinsMGMT, O^6^-methylguanine-DNA methyltransferaseMGO, MethylglyoxalMich, Michael addition reaction.MIF, Macrophage Migration Inhibitory FactorMIP-1β, Macrophage Inflammatory Protein‐1βMIP‑1α, CCL3MIP2, Macrophage Inflammatory Protein 2miR-125b, miR-125bmiR-126, miR-126miR-127-5p, miR-127-5pMiR-1275, MiR-1275miR-129-5p, miR-129-5pmiR-130a, miR-130a microRNAmiR-133a-3p, miR-133a-3pmiR-139-5p, miR-139-5pmiR-141, miR-141miR-142-3p, miR-142-3p microRNAmiR-143, miR-143miR-145, miR-145miR-148a, Micro RNA 148amiR-155, miR-155miR-192-5p, miR-192-5pmiR-19b, MicroRNA-19miR-200b, miR-200bmiR-200c, miR-200cmiR-203, miR-203miR-205, microRNA 205miR-21, miR-21miR-210, miR-210miR-215-5p, miR-215-5pmiR-218, miR-218miR-22, miR-22miR-25-5p, miR-25-5pmiR-27a-3p, miR-27a-3pmiR-29b, miR-29bmiR-301a-3p, miR-301a-3pmiR-30a-5p, miR-30a-5pmiR-320a, miR-320amiR-330-5p, miR-330-5pmiR-340, miR-340miR-34a, mir-34 precursor familymiR-34b-5p, miR-34b-5pmiR-384, miR-384miR-409-3p, miR-409-3pmiR-486, miR-486miR-497, miR-497miR-548ah-5p, miR-548ah-5pmiR-7641, miR-7641mitResp, mitochondrial respirationMKI67, MKI67 (coding for the protein Ki-67)MKK4, Mitogen-Activated Protein Kinase Kinase 4MKP1, MAP kinase phosphatase 1MKP2, MAP kinase phosphatase 2MKP5, MKP5MLH1, mutL homolog 1, colon cancer, nonpolyposis tMLKL, Mixed Lineage Kinase Domain-LikeMLL2, myeloid/lymphoid or mixed-lineage leukemia 2MLL3, myeloid/lymphoid or mixed-lineage leukemia 3MLPH, MelanophilinMMP, ΔΨm, mitochondrial membrane potentialMMP-10, Matrix Metalloproteinase-10MMP1, Matrix metalloproteinasesMMP1:TIMP1, MMP1:TIMP1 ratioMMP11, matrix metalloproteinase 11MMP13, MMP13MMP14, MMP14MMP17, Metalloproteinase 17MMP2, metalloproteinase-2MMP3, Matrix metalloproteinase-3MMP7, metalloproteinase-7MMP9, MMP9MMP9:TIMP1, MMP-9/TIMP-1 ratioMMPs, Matrix metalloproteinasesMOB1, MOB Kinase Activator 1Mortalin, mtHsp70motorD, motor functionmPGES-1, Microsomal prostaglandin E synthase-1MPL, myeloproliferative leukemia virus oncogeneMPO, myeloperoxidase (MPO)MPT, mitochondrial permeability transitionMRGPRF, Mas-related G-protein coupled receptor, meMRP, Multidrug Resistance-Associated ProteinMRP1, Multidrug Resistance Protein 1MSCmark, MSC markersMSCs, mesenchymal stem cellsMSH2, mutS homolog 2, colon cancer, nonpolyposis tMSH6, mutS homolog 6 (E. coli)Mst1, Mammalian Ste20-like kinase 1mtDam, mitochondrial damagemTOR, mammalian target of rapamycinmTORC1, mammalian target of rapamycin complex 1mTORC2, mammalian target of rapamycin (mTOR) complMUC1, Mucin 1MUC1-C, MUC1-CMUC4, mucin, a high-molecular-weight glycoproteinMyc, v-myc avian myelocytomatosis viral oncogene hMyD88, Myeloid differentiation factor 88N-cadherin, N-cadherinn-MYC, n-MYC OncogeneNA, NANAD, Nicotinamide adenine dinucleotideNADH, Nicotinamide Adenine DinucleotideNADH:NAD, NADH:NAD+ ratioNADHdeh, NADH dehydrogenasesNADPH, Nicotinamide adenine dinucleotide phosphateNADPH/NADP+, NADPH/NADP+ ratioNAF1, Neutrophil-activating factor 1NAIP, Neuronal Apoptosis Inhibitory ProteinNanog, human hNanog protein coded by the NANOG genNBR2, long noncoding RNA neighbor of BRCA1 lncRNA NCAM, Neural Cell Adhesion MoleculeNCOA4, Nuclear Receptor Coactivator 4NCOR1, nuclear receptor co-repressor 1NDRG1, N-myc Downstream Regulated Gene 1Necroptosis, Necroptosisnecrosis, necrosisNEDD9, Neural precursor cell expressed developmentNestin, NestinNetrins, NetrinsneuroG, neurogenesisNeurog1, Neurogenin 1neuroP, neuroprotectiveNeuroT, neurotensinNeut, neutrophilsNF-kB, Nuclear factor kappa BNF1, neurofibromin 1NF2, neurofibromin 2 (merlin)NFAM1, Neural Factor Activating Mast cells 1NFAT, nuclear factor of activated T cellsNFE2L2, nuclear factor (erythroid-derived 2)-like NH3, ammoniaNHE1, Na+/H+ exchanger isoform 1NHE3, Sodium/Hydrogen Exchanger 3NICD, Notch Intracellular DomainNK cell, NK cell activityNKD2, Naked cuticle homolog 2NKG2D, natural killer group 2, member D (NKG2D) liNKX3.1, Homeobox protein Nkx-3.1NLRP3, NOD-like receptor pyrin domain-containing pNM23, NM23NNMT, Nicotinamide N-methyltransferaseNO, Nitric OxideNOS2, nitric oxide synthase 2NOTCH, NOTCH1, Notch homolog 1, translocation-associated NOTCH2, Notch homolog 2 (Drosophila)NOTCH3, Notch homolog 3NOX, NADPH oxidaseNOX4, NADPH oxidase 4NOXA, Phorbol-12-myristate-13-acetate-induced protNPC1L1, Niemann–Pick C1-Like 1NPM1, nucleophosmin 1 (nucleolar phosphoprotein B2NPY, Neuropeptide YNQO1, NAD(P)H quinone dehydrogenase 1NQO2, N-ribosyldihydronicotinamide:quinone reductaNRAS, neuroblastoma RAS viral (v-ras) oncogene homNrf1, Nuclear factor erythroid 2-related factor 1NRF2, nuclear factor erythroid 2-related factor 2NSE, Neuron-specific enolasenucleolin, nucleolinOAA, oxaloacetateOATPs, Organic Anion Transporting PolypeptidesOATs, Organic Anion TransportersObesity, ObesityOCN, OsteocalcinOCR, Oxygen consumption rateOCT4, Octamer-binding transcription factor 4oncosis, OncosisOPG, OPGOPN, OsteopontinOS, overall survivalOSI, oxidative stress indexOSM, oncostatinother, otherOV6, OV6OXPHOS, Oxidative phosphorylationP-gp, permeability-glycoproteinp16, protein 16p19, p19/CDKN2DP21, p27, p27kip1P2X7, purinoceptor 7p300, p300p38, p38p42, p42 MAPKp44, p44/ERK1P450, cytochrome P450 (CYP) familyp50, p50P53, P53-Guardian of the Genomep53 Wildtype, p53 Wildtypep62, p62/sequestosome 1 (SQSTM1)p65, RelAp66Shc, p66Shcp70S6, phospho-S6P70S6K, p70 S6 kinasep73, p73p85S6K, isoform of S6 kinaseP90RSK, 90 kDa Ribosomal S6 KinasePain, PainPAK, p21-activated kinasesPAK1, PAO, PAO genePAR-2, Protease-activated receptor 2Paraptosis, ParaptosisPARK2, PARKINPARP, poly ADP-ribose polymerase (PARP) cleavagePARP1, Poly [ADP-ribose] polymerase 1PARP16, ARTD15pax, paxillinPAX5, paired box 5PBRM1, polybromo 1PCAF, p300/CBP-associated factorPCBP1, Poly(rC) Binding Protein 1PCK1, phosphoenolpyruvate carboxykinase 1PCLAF, Proliferating Cell Nuclear Antigen-AssociatPCNA, Proliferating Cell Nuclear AntigenPD-1, Programmed Death-1PD-L1, Programmed Death-Ligand 1PD-L2, Programmed Death-Ligand 2PDCD4, PDCD4 Programmed Cell Death 4PDGF, Platelet-derived growth factorsPDGFR-BB, Platelet-Derived Growth Factor Receptor PDGFRA, platelet-derived growth factor receptor, aPDH, mitochondrial pyruvate dehydrogenase (PDH)PDHA1, Pyruvate Dehydrogenase E1 Alpha 1 SubunitPDHB, pyruvate dehydrogenase E1 beta subunitPDI, Protein Disulfide IsomerasePDK1, Pyruvate dehydrogenase kinase 1PDK3, Pyruvate Dehydrogenase Kinase 3PDKs, pyruvate dehydrogenase kinasePDT+, PDT+cellsPerforin, PerforinPERK, protein kinase-like ER kinasePFK, PhosphofructokinasePFK1, Phosphofructokinase-1PFK2, PFK2PFKFB2, 6-Phosphofructo-2-Kinase/Fructose-2,6-BispPFKL, Phosphofructokinase, LiverPFKM, Phosphofructokinase, MusclePFKP, Phosphofructokinase, PlateletPGAM1, Phosphoglycerate mutase 1PGC-1α, Peroxisome proliferator-activated receptoPGC1A, PPARγ Coactivator 1-alphaPGD2, prostaglandin D2PGE1, Prostaglandin E1PGE2, Prostaglandin E2PGK1, Phosphoglycerate kinase 1PGM1, Phosphoglucomutase 1pH, PHDs, Prolyl HydroxylasesPHF6, PHD finger protein 6PI3K, Phosphatidylinositide-3-KinasesPI3K/Akt, PI3K/Akt signalingPI3k/Akt/mTOR, Phosphoinositide 3-kinase/Protein KPI3K/mTOR/ETS2, PI3K/mTOR/ETS2 pathwayPIAS-3, Protein Inhibitor of Activated STAT-3Piezo1, Piezo1PIK3CA, phosphoinositide-3-kinase, catalytic, alphPIK3R1, PIK3R1/p85S6 Phosphatidylinositol 3-kinasePin1, Peptidyl-prolyl cis-trans isomerase, NIMA-inPINK1, PTEN-induced kinase 1PIP3, Phosphatidylinositol (3,4,5)-trisphosphatePIR, Phosphoinositide-interacting regulator of TRPPirin, PirinPKA, protein kinase APKCδ, Protein Kinase C deltaPKL, liver isoform of pyruvate kinasePKM1, pyruvate kinase muscle isoform 1PKM2, Pyruvate Kinase, Muscle 2PKM2:PKM1, PKM2/PKM1 ratioPLC, perlecanPleEff, pleural effusionPLEKHM3, PLEKHM3PLIN1, Perilipin 1POLD1, POLD1polyA, polyaminePONs, paraoxonasePoor perfusion, Poor perfusionPPARα, Peroxisome Proliferator-Activated ReceptorPPARγ, Peroxisome proliferator-activated receptorPPP, pentose phosphate pathwayPPP2R1A, protein phosphatase 2 (formerly 2A), reguPR, Progesterone receptorPRAS40, proline-rich Akt substrate of 40 kDapRB, retinoblastoma proteinPRC2, Polycomb repressive complex 2PRDM1, PR domain containing 1, with ZNF domainPRKCG, Protein Kinase C GammaproApCas, proapoptotic cascadePRODH, proline dehydrogenaseproline, prolineProt, Protein LevelsProteasome, ProteasomePrx, PeroxiredoxinPrx3, peroxiredoxin-3Prx4, Peroxiredoxin 4Prx6, Peroxiredoxin 6PrxI, Peroxiredoxin IPrxII, Peroxiredoxin IIpS2/TFF1, pS2/TFF1PSA, prostate-specific antigenPSMB5, proteasome subunit beta type-5PTCH1, 12-transmembrane cell surface receptor PatcPTCH2, PTCH2PTEN, phosphatase and tensin homolog; phosphatase PTP1B, protein tyrosine phosphatase 1BPTPN11, protein tyrosine phosphatase, non-receptorPTPN6, SHP1/Protein Tyrosine Phosphatase, Non-RecePUMA, p53 upregulated modulator of apoptosisPYCR1, Pyrroline-5-Carboxylate Reductase 1Pyro, PyroptosisPyruv, PyruvateQoL, Quality of LifeR5P, ribose-5-phosphateRAAS, Renin-Angiotensin-Aldosterone SystemRac1, Ras-related C3 botulinum toxin substrate 1RAD51, RAD51radioP, RadioProtectiveRadioS, RadioSensitizerRaf, RAF kinasesRAGE, Receptor for advanced glycation end-productRANKL, Receptor Activator of Nuclear Factor κB LiRANTES, CCL5RARα, RARα (NR1B1)RARβ, RARβ (NR1B2)RARγ, RARγ (NR1B3)RAS, RASRB1, retinoblastoma 1 geneRBM3, RNA-binding motif protein 3RECK, Reversion Inducing Cysteine-Rich Protein witREL, V-rel avian reticuloendotheliosis viral oncogRemission, RemissionRenoP, K,RenoprotectionRET, Rearranged during Transfection proto-oncogeneRHBDD1, Rhomboid Domain Containing 1Rho, Rho GTPasesRIP1, Receptor-Interacting Protein 1RIP3, Receptor‐Interacting Protein Kinase 3Risk, RiskRNF43, ring finger protein 43RNR, Ribonucleotide ReductaseRNS, reactive nitrogen speciesROCK1, Rho-associated coiled-coil containing proteROMO1, Reactive Oxygen Species Modulator 1ROS, Reactive Oxygen SpeciesRPM, radical pair mechanismRPS6KA1, ribosomal protein S6 kinase alpha-1RPSA, Ribosomal Protein SARSK, Ribosomal S6 KinaseRTK-RAS, RTK-RASRUNX1, runt-related transcription factor 1RUNX2, Runt-related transcription factor 2S6, ribosomal protein S6S6K, S6 kinaseSA, Sialic acidSA of VW, Structural abnormalities of vessel wallsSAM-e, S-adenosylmethionineSAPK, stress-activated protein kinasesSAT1, Spermidine/Spermine N1-Acetyltransferase 1SCD1, Stearoyl-CoA Desaturase 1SCF, Stem Cell FactorSD, Stable DiseaseSDC1, Syndecan-1 (SDC-1)SDH, Succinate dehydrogenase/ComplexIISE-cad, Selenocysteine-containing enzyme glutathioSecurin, PTTG1selectivity, selectivityselenoP, selenoproteinsselm, seleniumSema3A/PlexinA1, Sema3A/PlexinA1Sepsis, SepsisserineP, serine proteaseSESN2, Sestrin 2Set9, SETD7 (SET domain containing lysine methyltrSETBP1, SET binding protein 1SETD2, SET domain containing 2SF3B1, splicing factor 3b, subunit 1, 155kDasFasL, soluble Fas LigandSFRP5, Secreted Frizzled-Related Protein 5SGLTs, Sodium-Glucose CotransportersSHARP, SHARP1/BHLHE41Sharpin, SHANK-associated RH domain interactorSHBG, Sex Hormone-Binding GlobulinShc, Shc signaling proteinsShh, sonic hedgehogSHP1, Src Homology region 2 domain-containing PhosSIRT1, Sirtuin 1 proteinSIRT2, Sirtuin 2SIRT3, Sirtuin 3SIRT6, Sirtuin 6SK, Sphingosine kinasesSLC12A5, SLC12A5SLC25A1, CICSleep, Sleep QualitySlug, transcription factor SlugSmad1, Smad1SMAD2, SMAD family member 2SMAD3, SMAD3SMAD4, SMAD family member 4SMAD5, SMAD5Smad7, Smad7SMARCA4, SWI/SNF related, matrix associated, actinSMARCB1, SWI/SNF related, matrix associated, actinSMCT1, SLC5A8SMG1, Suppressor of Morphogenetic Defects in GenitSmo, G-protein-coupled receptor-like 7-pass transmSnail, SnailSNCG, SNCG geneSOCS-3, Suppressor of Cytokine Signaling 3SOCS1, suppressor of cytokine signaling 1SOD, superoxide dismutaseSOD1, superoxide dismutase 1SOD2, MnSODsonoP, sonoporationsonoS, sonosensitizerSOX2, SOX2SOX4, SRY‐box transcription factor 4SOX9, SRY (sex determining region Y)-box 9Sp1/3/4, Specificity ProteinSPARC, secreted protein acidic and rich in cysteinSPOP, speckle-type POZ proteinSPP1, Secreted phosphoprotein 1Src, Src kinaseSRD5A1, SRD5A1SREBF2, Sterol Regulatory Element Binding Factor 2SREBP1, sterol regulatory element-binding protein SREBP2, Sterol Regulatory Element-Binding Protein SRSF2, SRSF2 serine/arginine-rich splicing factor SSAT, Spermidine/Spermine N1-AcetyltransferaseSSBP1, single-stranded DNA binding protein 1STAC2, SH3 and cysteine-rich domain 2STAG2, stromal antigen 2StAR, Steroidogenic Acute Regulatory proteinSTAT, Signal transducer and activator of transcripSTAT1, Signal transducer and activator of transcriSTAT2, Signal Transducer and Activator of TranscriSTAT3, Signal transducer and activator of transcriSTAT4, Signal transducer and activator of transcriSTAT5, Signal transducer and activator of transcriSTAT6, Signal Transducer and Activator of TranscriSTEAP3, Six Transmembrane Epithelial Antigen of thSTK11, serine/threonine kinase 11Strength, physical strengthSufu, Sufu genesurvivin, BIRC5SUZ12, Suppressor of zeste 12SVCT-2, Sodium-dependent Vitamin C Transporter 2SXR, PXR-Steroid and Xenobiotic ReceptorSymptoms, SymptomsT-cadherin, T-cadherin/CDH13T-Cell, T lymphocytesT-SOD, tissue superoxide dismutasesTAC, total antioxidant capacitytalin, talinTAMS, tumor-associated macrophagesTANs, tumor-associated neutrophilsTAp63α, TAp63αTarDef DNArep, Target deficient DNA repairTAS, Tumor Angiogenesis ScoreTASc, Tumor Angiogenesis Scoretau, tauTAZ, Transcriptional Coactivator with PDZ-binding TBARS, Thiobarbituric Acid Reactive SubstancesTBX15, T-box transcription factor 15TCA, Tricarboxylic Acid CycleTCF, T-cell factor (Tcf) familyTCF-4, Transcription Factor 4Telomerase, Telomerasetestos, testosteroneTET1, Ten-Eleven Translocation 1TET2, tet oncogene family member 2TET3, Ten-Eleven Translocation methylcytosine dioxTf, TransferrinTFAP2A, Transcription Factor AP-2 alphaTFEB, Transcription Factor EBTfR1/CD71, Transferrin receptor protein 1,TGF-β, transforming growth factor-betaTGF-β1, Transforming Growth Factor-Beta 1TGFβR1, transforming growth factor-beta receptor Th1 response, T helper responseTh17, T helper 17 (Th17) cellsTh2, Type 2 helper cellTHBS2, thrombospondin 2 geneThiols, ThiolsTILs, tumor-infiltrating lymphocytes (TILs)TIM-3, T-cell immunoglobulin and mucin-domain contTIMP1, Tissue Inhibitor of Metalloproteinases-1TIMP2, Tissue Inhibitor of Metalloproteinases-2TIMP3, tissue inhibitor of metalloproteinases-3TJ, Tight junctionsTKT, transketolaseTLR1, Toll-Like Receptor 1TLR2, Toll-Like Receptor 2TLR4, Toll-like receptor 4TLS, Tumor lysis syndromeTNC, tenascin-CTNF-α, TNF-αTNF-β, Tumor Necrosis Factor-betaTNFAIP3, tumor necrosis factor, alpha-induced protTNFR 1, Tumor necrosis factor receptor 1,TOP1, Topoisomerase ITOP2, Topoisomerase IITOPflash, TOPflashTOS, total oxidant statustoxicity, toxicityTP53, tumor protein p53TPI, Triosephosphate IsomeraseTPM4, Tropomyosin 4TRAF7, TNF receptor-associated factor 7TRAIL, tumor necrosis factor-related apoptosis-indTRAILR, tumor necrosis factor-related apoptosis-inTrans Reg, Transcriptional regulationTreg lymp, Treg lymphocytesTregCell, Treg cellsTREM-1, triggering receptor expressed on myeloid cTRIB3, tribbles homolog 3TRIF, Toll/IL-1 receptor domain-containing adaptorTrkB, Tropomyosin receptor kinase BTrop2, Trop2TRPM7, transient receptor potential melastatin 7TRPV1, transient receptor potential vanilloid 1Trx, ThioredoxinTrx1, Thioredoxin 1Trx2, thioredoxin 2TrxR, Thioredoxin ReductaseTrxR1, thioredoxin reductase 1TrxR2, thioredoxin reductase-mitochondrialtrypsin, trypsinTS, thymidylate synthaseTSC1, tuberous sclerosis 1TSC2, tuberous sclerosis complex (TSC)TSHR, thyroid stimulating hormone receptorTSP-1, Thrombospondin-1TumAuto, Tumor autophagyTumCA, Tumor Cell adhesionTumCCA, Tumor cell cycle arrestTumCD, Tumor Cell DeathTumCG, Tumor cell growthTumCI, Tumor Cell invasionTumCM/A, Tumor cell metabolism/acidosisTumCMig, Tumor cell migrationTumCP, Tumor Cell proliferationtumCV, Cell ViabilityTumMeta, Cancer MetastasisTumN, Tumor necrosisTumPF, Tumor-promoting fibroblastsTumPInf, Tumor-promoting inflammationTumVol, Tumor VolumeTumW, Tumor WeightTUNEL, Terminal deoxynucleotidyl transferase dUTP Twist, TwistTXA2, thromboxane A2TXNIP, TBP-2Tyro3, Tyro3tyrosinase, tyrosinaseU2AF1, U2 small nuclear RNA auxiliary factor 1UBE2C, Ubiquitin-conjugating enzyme E2 CUCP1, mitochondrial uncoupling protein 1UHRF1, Ubiquitin-like with PHD and RING Finger domuPA, Urokinase plasminogen activatoruPAR, Urokinase-type plasminogen activator receptoUPR, Unfolded Protein ResponseuricA, uric acidUrinaryC, urinary continenceUroPA, Urokinase plasminogen activatorUSF1, Upstream transcription factor 1VCAM-1, Vascular cell adhesion protein 1VDR, Vitamin D receptorVEGF, Vascular endothelial growth factorVEGFR2, Vascular Endothelial Growth Factor ReceptoVGCC, Voltage-gated calcium channelsVHL, von Hippel-Lindau tumor suppressorVim, Vimentinvinculin, vinculinVitC, Vitamin C levelsVitD, Vitamin DVitE, Vitamin E levelsVM, vasculogenic mimicryWarburg, Warburg EffectWeight, WeightWmax, WmaxWnt, Wingless-related integration siteWnt/(β-catenin), Wnt/(β-catenin)WT1, Wilms tumor 1XBP-1, X-box binding protein 1xCT, SLC7A11XIAP, X-linked inhibitor of apoptosis protein (XIAXIST, X-inactive specific transcriptYAP/TEAD, YAP/TEAD activityYMcells, YOUNG’S MODULUS cancer cellsZBTB10, ZBTB transcription Factor 10Zeb1, Zinc finger E-box-binding homeobox 1ZEB2, Zinc Finger E-Box Binding Homeobox 2ZFX, Zinc Finger X-linkedZO-1, Zonula occludens-1α-SMA, α-smooth muscle actinα-tubulin, α-tubulinβ-Amyloid, β-Amyloid Fibrilsβ-catenin/ZEB1, β-catenin/ZEB1β-Endo, β-Endorphinβ-oxidation, Beta Oxidationβ-TRCP, beta-transducin repeat-containing proteinγH2AX, gamma-H2AXγδ T-cell activity, γδ T-cell activity     View: by ID num 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tid		Target	PKL	Cancers General Effect on Target	?↓↑⇅↝?∅

Name	liver isoform of pyruvate kinase
Source
Type

<b>PKL</b> refers to the liver isoform of pyruvate kinase, an enzyme that catalyzes the final step of glycolysis.<br> <br> • PKL is normally highly expressed in liver tissue and is involved in efficiently channeling glycolytic intermediates into pyruvate and subsequently into energy production pathways.<br> <br> • In cancer, metabolic reprogramming (the Warburg effect) is widespread. While many tumors adopt the PKM2 isoform to support rapid proliferation, alterations in PKL expression have been observed particularly in liver cancers, and some extrahepatic tumors where pancreatic or biliary differentiation is involved.<br>

PKL refers to the liver isoform of pyruvate kinase, an enzyme that catalyzes the final step of glycolysis.

• PKL is normally highly expressed in liver tissue and is involved in efficiently channeling glycolytic intermediates into pyruvate and subsequently into energy production pathways.

• In cancer, metabolic reprogramming (the Warburg effect) is widespread. While many tumors adopt the PKM2 isoform to support rapid proliferation, alterations in PKL expression have been observed particularly in liver cancers, and some extrahepatic tumors where pancreatic or biliary differentiation is involved.




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