GSDMC (Gasdermin C) is a member of the gasdermin family, proteins that have garnered attention for their role in pyroptosis—a form of programmed cell death associated with inflammation—and for their emerging implications in cancer.
• Several studies have reported dysregulation of GSDMC in a range of tumors. In some cancers, such as colorectal, lung, and gastric cancers, GSDMC expression has been found to be upregulated compared to normal tissue.
• The increased expression of GSDMC in these cancers is thought to be linked not only to cell death pathways but also to the modulation of the tumor microenvironment, potentially influencing tumor progression.
• Elevated GSDMC expression in some cancers has been associated with more aggressive tumor behavior. For instance, higher levels of GSDMC have been correlated with advanced stages, increased metastasis, and poorer overall survival in certain studies.
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