PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 2) is one of the isoenzymes responsible for regulating the intracellular levels of fructose-2,6-bisphosphate, a key activator of phosphofructokinase-1 (PFK-1) in glycolysis. Its role in cancer metabolism is of increasing interest due to its involvement in regulating glycolytic flux.
• In many cancers, increased glycolytic activity is a hallmark. Upregulation of PFKFB2 in some tumors can contribute to this metabolic reprogramming, although expression patterns may be context- and tissue-specific.
• Both upregulation and, in some settings, downregulation have been reported, reflecting the enzyme’s complex involvement in metabolic regulation and potential feedback mechanisms within the tumor microenvironment.
• Some studies have correlated high PFKFB2 expression with aggressive tumor characteristics, such as increased proliferation, enhanced glycolysis, and potentially poorer clinical outcomes.
• In certain cancers, elevated levels of PFKFB2 may indicate a metabolic phenotype that favors tumor growth and resistance to stress, potentially serving as a marker of poor prognosis.
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