-MDMX, together with its homolog MDM2, is a critical negative regulator of the tumor suppressor protein p53.
-MDMX is often overexpressed in multiple cancer types through gene amplification, transcriptional upregulation, or other post-transcriptional mechanisms.
-Elevated MDMX levels can contribute to an environment of p53 inhibition, even in tumors that retain wild-type p53, thereby supporting cell proliferation and survival.
(Will delete Record if Target field = "Delete") Home