Topoisomerase II (Top2) is a critical nuclear enzyme involved in managing the topology of DNA during essential cellular processes like replication, transcription, recombination, and chromosomal segregation.
- Rapidly dividing cells, including many cancer cells, often show higher Top2 expression.
- In several cancers, such as breast, lung, and hematological malignancies, increased Top2 expression has been correlated with more aggressive tumor subtypes and poorer clinical outcomes.
- The level of Top2 expression can sometimes be used as a prognostic marker, informing predictions about disease progression and potentially patient survival.
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