Aquaporins are membrane proteins that form channels to facilitate water transport across cell membranes. They are essential for maintaining water homeostasis in various tissues, and research over the past decade has revealed their involvement in several aspects of cancer biology.
• Aquaporins can influence cell proliferation. Some studies have shown that overexpression of specific aquaporin isoforms (like AQP1, AQP3, and AQP5) is associated with increased cell proliferation in different cancer types.
-increased expression of AQP1 or AQP3 has been correlated with poor prognosis in some cancers.
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