Choline is an essential nutrient involved in multiple cellular functions including membrane biosynthesis (as part of phosphatidylcholine), methyl group metabolism, and cholinergic neurotransmission.
– Elevated levels of choline-containing compounds, often measured via magnetic resonance spectroscopy (MRS) or positron emission tomography (PET) using radiolabeled choline analogues, are frequently reported.
– High choline uptake or increased levels of choline metabolites generally correlate with higher tumor grade, greater aggressiveness, and poorer overall survival.
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