GPX3, or Glutathione Peroxidase 3, is an enzyme that plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and other peroxides.
Glutathione peroxidase 3 (GPX3) is another member of the glutathione peroxidase family, primarily found in extracellular spaces and secreted into the bloodstream. It plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and organic peroxides.
GPX3 can act as a tumor suppressor, as its expression is often downregulated in various types of cancer, including breast, prostate, and colorectal cancers. Lower levels of GPX3 may lead to increased oxidative stress, which can promote cancer cell proliferation and survival.
Conversely, in some contexts, GPX3 may also be associated with cancer progression, particularly in the tumor microenvironment, where it can influence the behavior of cancer cells and their interactions with surrounding tissues.
GPX3 expression is often decreased in various cancers and is generally associated with poorer prognosis due to its role in protecting cells from oxidative stress. The downregulation of GPX3 can lead to increased oxidative damage, promoting tumor progression and aggressiveness.
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