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tid Target Cancers General Effect on Target
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Choline acetyltransferase (ChAT) is the enzyme responsible for synthesizing acetylcholine (ACh), a key neurotransmitter involved in memory, learning, and attention.
In AD, one of the hallmark neurochemical findings is a loss of cholinergic neurons, especially in the basal forebrain, leading to:
↓ ChAT activity
↓ Acetylcholine (ACh) levels
↓ Cognitive function (especially memory and attention)

Many AD drugs aim to increase ACh levels by:
-Inhibiting acetylcholinesterase (AChE) (which breaks down ACh), e.g., donepezil, rivastigmine.




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