Monoamine oxidase B (MAO-B) is an enzyme involved in the metabolism of monoamines, especially dopamine and phenylethylamine, primarily in the brain. Its activity has been implicated in both Alzheimer's disease (AD) and cancer, but in very different contexts.
-Increased MAO-B expression is observed in the brains of aging individuals and even more so in AD patients, particularly in astrocytes.
-High MAO-B activity may accelerate β-amyloid (Aβ) and tau pathology.
-MAO-B inhibitors are potential agents to combat neurodegenerative diseases, including AD and Parkinson’s disease
MAO-B inhibitors have shown anti-cancer effects in preclinical models:
Inducing apoptosis in tumor cells.
Sensitizing cells to chemotherapy or radiotherapy.
Inhibiting tumor angiogenesis and invasion.
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