Phosphodiesterase 4 (PDE4) has been increasingly implicated in the pathology of Alzheimer's Disease (AD), primarily due to its role in regulating cyclic AMP (cAMP) signaling in the brain.
-Hydrolyzes cAMP → AMP (thus decreasing cAMP levels)
-PDE4 inhibitors (like rolipram): Enhance memory in AD mouse models
Possible inhibitors:
Resveratrol, Baicalin, Luteolin, Quercetin, Apigenin, Icariin
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