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tid		Target	H2O2	Cancers General Effect on Target

Name	Hydrogen peroxide (H2O2)
Source
Type

<b>H2O2</b> is a reactive oxygen species (ROS) that can induce oxidative stress in cells. While low levels of ROS can promote cell signaling and proliferation, high levels can lead to DNA damage, apoptosis (programmed cell death), and other cellular dysfunctions. This dual role means that H2O2 can contribute to cancer development and progression, as oxidative stress can lead to mutations and genomic instability.<br>
H2O2 can enhance the effectiveness of certain chemotherapeutic agents by increasing oxidative stress in cancer cells. Additionally, localized delivery of H2O2 has been explored as a means to selectively target and kill cancer cells while sparing normal cells.<br>
Cancer cells often exhibit altered metabolism, leading to increased production of reactive oxygen species, including H2O2. This can result from enhanced mitochondrial activity, increased glycolysis, or other metabolic adaptations that are characteristic of cancer.<br>
<br>
<br>
Reported H2O2 concentrations for representative compounds.<br>
<table>
  <thead>
    <tr><th>   Prooxidant   </th><th>       Dose       </th><th>            Cell Line            </th><th>H2O2 Produced</th></tr>
  </thead>
  <tbody>
    <tr><td>EGCG</td><td>50 µM</td><td>Jurkat</td><td>~1 µM</td></tr>
    <tr><td>EGCG</td><td>10 µM</td><td>HCT116 and HT29</td><td>1.5 µM</td></tr>
    <tr><td>EGCG</td><td>100 µM</td><td>Jurkat</td><td>20 µM</td></tr>
    <tr><td>Quercetin</td><td>70 µM</td><td>HT29</td><td>2 µM</td></tr>
    <tr><td>Menadione</td><td>10 µM</td><td>Jurkat</td><td>20 µM</td></tr>
    <tr><td>Plumbagin</td><td>4 µM</td><td>SiHA and HeLa</td><td>1 mM</td></tr>
    <tr><td>β-Lap</td><td>1 µM</td><td>HL-60</td><td>70 µM</td></tr>
    <tr><td>Doxorubicin</td><td>1 µM</td><td>PC3</td><td>38 pM</td></tr>
    <tr><td>Ascorbic Acid </td><td>1 mM</td><td>HL-60</td><td>161 µM</td></tr>
    <tr><td>Ascorbic Acid</td><td>0.2–2.0 mM</td><td>Lymphoma</td><td>20–120 µM</td></tr>
    <tr><td>Ascorbic Acid</td><td>i.v. 0.5 mg/g</td><td>Rats</td><td>0–20 µM</td></tr>
    <tr><td>Ascorbic Acid</td><td>i.p. 4.0 g/kg</td><td>Mice tumor</td><td>> 125 µM</td></tr>
    <tr><td>TiO2</td><td>10 µg/mL</td><td>HepG2</td><td>150 nmol/mL</td></tr>
    <tr><td>Paclitaxel</td><td>100 nM</td><td>MCF7</td><td>600 nM</td></tr>
    <tr><td>Paclitaxel</td><td>100 nM</td><td>HL-60</td><td>1100 nM</td></tr>
  </tbody>
</table>

<br>
Note: many products at lower concentrations act as antioxidants, instead of Prooxidants.<br>
<br>
Generally, increased hydrogen peroxide and oxidative stress are associated with poor outcomes, while the specific context and cellular environment can modulate its effects.<br>

H2O2 is a reactive oxygen species (ROS) that can induce oxidative stress in cells. While low levels of ROS can promote cell signaling and proliferation, high levels can lead to DNA damage, apoptosis (programmed cell death), and other cellular dysfunctions. This dual role means that H2O2 can contribute to cancer development and progression, as oxidative stress can lead to mutations and genomic instability.
H2O2 can enhance the effectiveness of certain chemotherapeutic agents by increasing oxidative stress in cancer cells. Additionally, localized delivery of H2O2 has been explored as a means to selectively target and kill cancer cells while sparing normal cells.
Cancer cells often exhibit altered metabolism, leading to increased production of reactive oxygen species, including H2O2. This can result from enhanced mitochondrial activity, increased glycolysis, or other metabolic adaptations that are characteristic of cancer.

Reported H2O2 concentrations for representative compounds.

Prooxidant	Dose	Cell Line	H2O2 Produced
EGCG	50 µM	Jurkat	~1 µM
EGCG	10 µM	HCT116 and HT29	1.5 µM
EGCG	100 µM	Jurkat	20 µM
Quercetin	70 µM	HT29	2 µM
Menadione	10 µM	Jurkat	20 µM
Plumbagin	4 µM	SiHA and HeLa	1 mM
β-Lap	1 µM	HL-60	70 µM
Doxorubicin	1 µM	PC3	38 pM
Ascorbic Acid	1 mM	HL-60	161 µM
Ascorbic Acid	0.2–2.0 mM	Lymphoma	20–120 µM
Ascorbic Acid	i.v. 0.5 mg/g	Rats	0–20 µM
Ascorbic Acid	i.p. 4.0 g/kg	Mice tumor	> 125 µM
TiO2	10 µg/mL	HepG2	150 nmol/mL
Paclitaxel	100 nM	MCF7	600 nM
Paclitaxel	100 nM	HL-60	1100 nM

Note: many products at lower concentrations act as antioxidants, instead of Prooxidants.

Generally, increased hydrogen peroxide and oxidative stress are associated with poor outcomes, while the specific context and cellular environment can modulate its effects.

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