Prion Protein (PRioN Protein) gene
-Upregulation of PRNP → Activates PI3K/Akt, MAPK/ERK, and NF-κB pathways → ↑ cell survival, ↓ apoptosis, ↑ migration/invasion.
-Silencing or downregulation of PRNP often reduces tumor growth and increases chemosensitivity.
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