H3 histone, family 3B (H3.3B); H3 histone, family 3A pseudogene; H3 histone, family 3A; similar to H3 histone, family 3B; similar to histone H3.3B
H3F3A is a gene that encodes a variant of the histone H3 protein, which is a crucial component of chromatin in eukaryotic cells. Histones play a significant role in the regulation of gene expression and the structural organization of DNA.
Alterations or mutations in the H3F3A gene, particularly in the context of specific amino acid substitutions, have been associated with certain types of cancer, most notably gliomas, which are tumors that occur in the brain and spinal cord.
H3F3A plays a significant role in cancer biology, particularly through its involvement in chromatin regulation and gene expression. Mutations in H3F3A, especially the H3.3K27M variant, are associated with aggressive tumor behavior and poor prognosis in several cancer types, particularly glioblastoma and pediatric brain tumors.
While H3F3A itself is not an oncogene, the mutations in this gene can drive oncogenic pathways and contribute to the development and progression of tumors.
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