An enzyme that plays a significant role in the metabolism of the amino acid tryptophan. It is involved in the kynurenine pathway, which leads to the production of several metabolites that can influence immune responses and have implications in cancer.
IDO has garnered attention for its role in immune evasion. Many tumors express IDO, which can lead to local depletion of tryptophan and accumulation of kynurenine and other metabolites. This can suppress T-cell activity and promote the differentiation of regulatory T cells, thereby helping tumors evade the immune system.
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