ARID1A gene is involved in chromatin remodeling, a process that regulates gene expression and cell growth. The precise role of ARID1A in cancer is highly variable since ARID1A alterations can have a tumor suppressive or oncogenic role, depending on the tumor type and context. ARID1A is mutated in about 10% of all tumor types including endometrial, bladder, gastric, liver, biliopancreatic cancer, some ovarian cancer subtypes, and the extremely aggressive cancers of unknown primary. Its loss is generally associated with disease progression more often than onset.
ARID1A is a significant player in cancer biology, particularly in ovarian and endometrial cancers. Its mutations are associated with poor prognosis and may influence treatment responses.
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